PF-4840154

PF-4840154 is a transient receptor potential ankyrin 1 (TRPA1) agonist. It induces calcium influx into HEK293 cells expressing recombinant human or rat TRPA1 (EC50s = 23 and 97 nM, respectively). Intraplantar injection of PF-4840154 (30 nmol) increases paw licking time in mice in a TRPA1-dependent manner.Formal Name: 4-[(2-methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide. CAS Number: 1332708-14-1. Molecular Formula: C26H38N6O2. Formula Weight: 466.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 234, 265, 311 nm. SMILES: O=C(NCC1=CC=CC=C1)C2=C(NCC(C)C)N=C(N3CCN(CC4COCCC4)CC3)N=C2. InChi Code: InChI=1S/C26H38N6O2/c1-20(2)15-27-24-23(25(33)28-16-21-7-4-3-5-8-21)17-29-26(30-24)32-12-10-31(11-13-32)18-22-9-6-14-34-19-22/h3-5,7-8,17,20,22H,6,9-16,18-19H2,1-2H3,(H,28,33)(H,27,29,30). InChi Key: PPANZCQXFYBGHN-UHFFFAOYSA-N.