PF-05221304

Description: PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis. Target: Acetyl-CoA Carboxylase. Smiles: O=C1CC2(CC3=C1N(C(C)C)N=C3)CCN(C(=O)C=4C=C(N=C(OC)C4)C5=CC=C(C(O)=O)C=C5)CC2. References: Ross T T , Crowley C , Kelly K L , et al. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems[J]. Cellular and Molecular Gastroenterology and Hepatology, 2020, 10(4).