Zu "K01946" wurden 24 Artikel gefunden!
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Anti-ACACB / Acetyl-CoA carboxylase 2
Artikelnummer: NSJ-RQ8875
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. It is mapped to 12q24.11. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes...
| Schlagworte: | Anti-ACACB, Anti-ACC-beta, Anti-Acetyl-CoA carboxylase 2, ACACB Antibody / Acetyl-CoA carboxylase 2 |
| Anwendung: | WB, IHC (paraffin), FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Olumacostat Glasaretil
Artikelnummer: Cay44262-10
Olumacostat glasaretil is an inhibitor of acetyl-CoA carboxylase (ACC). It increases the ratio of acetyl-CoA to free CoA in hamster ear sebaceous glands when applied topically at a concentration of 6% (w/w). Olumacostat glasaretil (0.3, 1, or 3 µM) inhibits triacylglycerol formation induced by T0901317 (Cay-71810)...
| Schlagworte: | DRM01, 5-(tetradecyloxy)-2-furancarboxylic acid, 2-[(2-ethoxy-2-oxoethyl)methylamino]-2-oxoethyl ester |
| Anwendung: | Acetyl-CoA carboxylase (ACC) inhibitor |
| CAS | 1261491-89-7 |
| MW: | 481.63 D |
ab 88,00 €
Acetyl-Coenzyme A Carboxylase 2 (ACC2) Assay Kit
Artikelnummer: BPS-79282
Acetyl-Coenzyme A Carboxylase (ACC) plays an important role in fatty acid metabolism so it has been proposed to be a drug target for the fatty acid-related metabolic diseases including obesity and diabetes. The Acetyl-Coenzyme A Carboxylase 2 (ACC2) assay kit is designed to measure ACC2 activity for screening and...
| Schlagworte: | acetyl-coa carboxylase acetyl coa acetyl coenzyme a ACC2, acetyl-Coenzyme A carboxylase alpha transcript variant 2, ACC-2,... |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.351,00 €
ACC-2, active human recombinant protein
Artikelnummer: BPS-50201
Active Human ACC2 (GenBank Accession No. NM_001093), full length, with C-terminal HIS tag, MW=277 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | ACC2, ACC-beta, Acetyl-CoA carboxylase 2, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 277 kD |
916,00 €
PF-05175157
Artikelnummer: Cay21778-1
PF-05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively). It inhibits formation of malonyl-CoA in primary rat hepatocytes (EC50 = 29.9 nM). In vivo, PF-05175157 inhibits formation of malonyl-CoA in the...
| Schlagworte: | 1,4-dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one |
| Anwendung: | ACC inhibitor |
| CAS | 1301214-47-0 |
| MW: | 405.5 D |
ab 50,00 €
ND-646
Artikelnummer: Cay34764-1
ND-646 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 3.5 and 4.1 nM, respectively, for the human enzymes). It inhibits the production of palmitate and reduces the total fatty acid content in A549 non-small cell lung cancer (NSCLC) cells when used at a concentration of 500 nM. ND-646 (500 nM)...
| Schlagworte: | 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-alpha,alpha,5-trimethyl-6-(2-oxazolyl)-2,4... |
| Anwendung: | Acetyl-CoA carboxylase inhibitor |
| CAS | 1434639-57-2 |
| MW: | 568.6 D |
ab 92,00 €
Anti-ACACB
Artikelnummer: NSJ-R35351-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Acetyl-Coenzyme A carboxylase beta Protein function: Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin...
| Schlagworte: | Anti-ACC2, Anti-ACACB, Anti-ACC-beta, EC=6.3.4.14, Anti-Biotin carboxylase, Anti-Acetyl-CoA carboxylase 2, ACACB Antibody |
| Anwendung: | ELISA (peptide), EIA |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
ND-630
Artikelnummer: Cay23961-10
ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 µM. ND-630...
| Schlagworte: | Firsocostat, GS-0976,... |
| Anwendung: | ACC inhibitor |
| CAS | 1434635-54-7 |
| MW: | 569.6 D |
ab 103,00 €
ND-630
Artikelnummer: BPS-27071-2
ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks...
| Schlagworte: | ND630, |
| Anwendung: | ACC1 / ACC2 inhibitor |
| MW: | 569,63 D |
ab 378,00 €
Anti-ACACB
Artikelnummer: ATA-HPA006554.100
Protein function: Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent...
| Schlagworte: | Anti-ACC2, Anti-ACC-beta, Anti-Acetyl-CoA carboxylase 2 |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
PF-05221304
Artikelnummer: Cay36856-1
PF-05221304 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 12.4 and 8.7 nM, respectively). It inhibits de novo lipid synthesis (IC50 = 61 nM) and increases fatty acid oxidation in primary human hepatocytes. PF-05221304 reduces the accumulation of triglycerides composed of de novo-derived fatty...
| Schlagworte: | Clesacostat,... |
| Anwendung: | Acetyl-CoA carboxylase (ACC1/ACC2) inhibitor |
| CAS | 1370448-25-1 |
| MW: | 502.6 D |
ab 122,00 €
Olumacostat Glasaretil
Artikelnummer: TGM-T3510-100mg
Description: Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris. Target: Acetyl-CoA Carboxylase. Smiles: CCCCCCCCCC CCCCOc1ccc(o1)C(=O)OCC(=O)N(C)CC(=O)OCC. References: Hunt DW, et al. Inhibition of Sebum...
| Anwendung: | Targets acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15] (ACACA) |
| CAS | 1261491-89-7 |
| MW: | 481.62 D |
ab 42,00 €