Peldesine

Description: Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection. Target: HIV Protease, Nucleoside Antimetabolite/Analog. Smiles: C(C=1C2=C(NC1)C(=O)N=C(N)N2)C=3C=CC=NC3. References: Wada Y, et al. BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. Artif Organs. 1996 Aug,20(8):849-52.