PD 81723

An adenosine A1 receptor positive allosteric modulator, inhibits TNF-a and cycloheximide-induced apoptosis in HK-2 kidney epithelial cells at 10 µM, increases right atrial heart rate in combination with ADA in isolated rat right atria (EC50 = 0.83 nM), reduces plasma creatinine levels and infarct area in a mouse model of renal ischemia-reperfusion injury at 3 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3. InChIKey: KKDKAWKYGCUOGR-UHFFFAOYSA-N. SMILES: O=C(C1=C(N)SC(C)=C1C)C2=CC=CC(C(F)(F)F)=C2