Zu "K04265" wurden 99 Artikel gefunden!
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FK-453
Artikelnummer: Cay45327-1
FK-453 is an adenosine A1 receptor antagonist (Ki = 18 nM). It is selective for the adenosine A1 receptor over the adenosine A2A and A3 receptors (Kis = 1,300 and 2,800 nM, respectively). FK-453 reduces adenosine-induced negative inotropic activity in isolated guinea pig atrial strips (IC50 = 560 pM).2 It has...
| Schlagworte: | (2E)-1-[(2R)-2-(2-hydroxyethyl)-1-piperidinyl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2-propen-1-one |
| Anwendung: | Adenosine A1 receptor antagonist |
| CAS | 121524-18-3 |
| MW: | 375.47 D |
ab 174,00 €
A1AR Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-00892-10ug
Description: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. A1AR Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 39.3 kDa and the accession number is P30542.
| Schlagworte: | ADORA1 , Adenosine receptor A1 |
| MW: | 39.3 kD |
ab 497,00 €
5'-N-Ethylcarboxamidoadenosine (hydrate)
Artikelnummer: Cay21420-5
5'-N-Ethylcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively). NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC50 = 3.1...
| Schlagworte: | Adenosine 5'-ethylcarboxamide, NECA, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide, hydrate |
| Anwendung: | Adenosine receptor agonist |
| MW: | 308.3 D |
ab 51,00 €
PD 81723
Artikelnummer: Cay42371-10
An adenosine A1 receptor positive allosteric modulator, inhibits TNF-a and cycloheximide-induced apoptosis in HK-2 kidney epithelial cells at 10 µM, increases right atrial heart rate in combination with ADA in isolated rat right atria (EC50 = 0.83 nM), reduces plasma creatinine levels and infarct area in a mouse...
| Schlagworte: | LY202472, (2-amino-4,5-dimethyl-3-thienyl)[3-(trifluoromethyl)phenyl]-methanone |
| Anwendung: | Adenosine A1 receptor positive allosteric modulator (PAM) |
| CAS | 132861-87-1 |
| MW: | 299.3 D |
ab 137,00 €
5'-Deoxy-5'-methylthioadenosine
Artikelnummer: Cay15593-100
5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher...
| Schlagworte: | 5'-S-Methylthioadenosine, MTA, NSC 335422, Vitamin L2, 5'-S-methyl-5'-thio-adenosine |
| Anwendung: | Intermediate, adenosine receptor agonist |
| CAS | 2457-80-9 |
| MW: | 297.3 D |
ab 65,00 €
2-Chloroadenosine
Artikelnummer: Cay15612-10
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively. CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized...
| Schlagworte: | Antibiotic AT-265B, CADO, NSC 36896, 2-chloro-adenosine |
| Anwendung: | Adenosine A1/A2A/A3 receptor agonist |
| CAS | 146-77-0 |
| MW: | 301.7 D |
ab 51,00 €
5'-Deoxy-5'-methylthioadenosine-d3
Artikelnummer: Cay27836-5
5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA (Cay-15593) by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of...
| Schlagworte: | 5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3, 5'-S-(methyl-d3)-5'-thio-adenosine |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification |
| CAS | 174838-38-1 |
| MW: | 300.3 D |
ab 89,00 €
Caffeine
Artikelnummer: Cay14118-5
| Schlagworte: | Methyltheobromine, NSC 5036, 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
| Anwendung: | Adenosine receptor antagonist |
| CAS | 58-08-2 |
| MW: | 194.2 D |
ab 44,00 €
Theobromine
Artikelnummer: Cay21745-25
Theobromine is a methylxanthine alkaloid and derivative of caffeine (Cay-14118) that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist (IC50s = 200-280 µM in radioligand binding assays using rat brain membranes). Theobromine (150 µg/ml) increases AMPK...
| Schlagworte: | Diurobromine, NSC 5039, SC-15090, 3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione |
| Anwendung: | Adenosine receptor antagonist |
| CAS | 83-67-0 |
| MW: | 180.2 D |
ab 51,00 €
7-Methylxanthine
Artikelnummer: Cay34348-50
7-Methylxanthine is an adenosine A1 receptor antagonist and active metabolite of theobromine (Cay-21745) and caffeine (Cay-14118). It inhibits binding of the adenosine A1 receptor agonist cyclohexyladenosine in rat cerebral cortical membranes in a concentration-dependent manner. 7-Methylxanthine (300 mg/kg) inhibits...
| Schlagworte: | 7-MX, NSC 7861, 3,7-dihydro-7-methyl-1H-purine-2,6-dione |
| Anwendung: | Active theobromine / caffeine metabolite, adenosine A1 receptor antagonist |
| CAS | 552-62-5 |
| MW: | 166.1 D |
ab 76,00 €
5'-Methylthioadenosine
Artikelnummer: TGM-T8227-25mg
Description: 4-Methyl-2-oxopentanoic acid is an abnormal metabolite, a neurotoxin and a metabolic toxin. Target: Endogenous Metabolite. Smiles: CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12. References: Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov,36(11):2125-30.
| Schlagworte: | 5'-S-Methyl-5'-thioadenosine, 5'-Deoxy-5'-(methylthio)adenosine, Methylthioadenosine, 5'-(Methylthio)-5'-deoxyadenosine |
| Anwendung: | Intermediate, adenosine receptor agonist |
| CAS | 2457-80-9 |
| MW: | 297.33 D |
ab 38,00 €
KW 3902
Artikelnummer: Cay11940-10
KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM). It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1, Ki = 7.82 µM). KW 3902 exhibits renal protective effects during...
| Schlagworte: | MK-7418, Rolofylline, 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione |
| Anwendung: | Adenosine A1 receptor antagonist |
| CAS | 136199-02-5 |
| MW: | 356.5 D |
ab 51,00 €