PD 166793

PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 µM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It reverses peroxynitrite-induced decreases in contraction cease time, a measure of cardiac contractility, in isolated rat ventricular myocytes when used at a concentration of 2 µM. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. It reduces LV dilation and preserves systolic function in a rat model of progressive heart failure. PD 166793 also inhibits age-associated increases in aortic gelatinase and interstitial collagenase activity and mean arterial pressure in rats.Formal Name: N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine. CAS Number: 199850-67-4. Molecular Formula: C17H18BrNO4S. Formula Weight: 412.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 204, 272 nm. SMILES: BrC1=CC=C(C2=CC=C(S(N[C@@H](C(C)C)C(O)=O)(=O)=O)C=C2)C=C1. InChi Code: InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1. InChi Key: GJOCABIDMCKCEG-INIZCTEOSA-N.