PD 151746

Description: PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 µM) over m-calpain (Ki = 5.33 ± 0.77 µM). Its IC50 values are 0.26 ± 0.03 µM (Ki for µ-calpain) and 5.33 ± 0.77 µM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2]. Target: Proteasome, Cysteine Protease. Smiles: OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12. References: Wang KK, et al. Proc Natl Acad Sci U S A. 1996, 93(13), 6687-6692.