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PD 151746
Artikelnummer: Cay23417-10
PD 151746 is an inhibitor of calpain 1/µ-calpain (Ki = 0.26 µM). It is 20-fold selective for calpain 1 over calpain 2/m-calpain (Ki = 5.33 µM). It is also selective over cathepsin B, papain, trypsin, and thermolysin, (Kis = >200, >500, >500, and >500 µM, respectively) and does not inhibit basal calcineurin activity...
| Schlagworte: | 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid |
| Anwendung: | Calpain-1 inhibitor |
| CAS | 179461-52-0 |
| MW: | 237.2 D |
ab 111,00 €
PD 151746
Artikelnummer: TGM-T2493-10mg
Description: PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 µM) over m-calpain (Ki = 5.33 ± 0.77 µM). Its IC50 values are 0.26 ± 0.03 µM (Ki for µ-calpain) and 5.33 ± 0.77 µM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity...
| Anwendung: | Calpain-1 inhibitor |
| CAS | 179461-52-0 |
| MW: | 237.25 D |
ab 34,00 €
