PD 123319 (trifluoroacetate salt)

Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct receptors: AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor). AT1R activation facilitates the 'classical' effects, including vasoconstriction, cellular growth, and proliferation, whereas AT2R activation offsets AT1R-mediated actions, promoting vasodilatation, apoptosis, and anti-growth effects. PD 123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R). It has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.Formal Name: (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid, di(2,2,2-trifluoroacetate). CAS Number: 136676-91-0. Molecular Formula: C31H32N4O3 . 2CF3COOH. Formula Weight: 736.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(O)[C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(N(CC5=CC=C(N(C)C)C(C)=C5)C=N4)C1.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24,2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38),2*(H,6,7)/t28-,,/m0../s1. InChi Key: GPKQIEZLHVGJQH-ZXVJYWQYSA-N.