Zu "K04167" wurden 55 Artikel gefunden!
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PD 123319 (trifluoroacetate salt)
Artikelnummer: Cay16099-5
Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct receptors: AT1R (angiotensin type 1 receptor) and AT2R (angiotensin...
| Schlagworte: | (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-ca... |
| Anwendung: | AT2R antagonist |
| CAS | 136676-91-0 |
| MW: | 736.7 D |
ab 145,00 €
AT2 Agonist C21
Artikelnummer: Cay33758-1
AT2 agonist C21 is an agonist of the angiotensin II type 2 (AT2) receptor. It selectively binds to the AT2 receptor over the AT1 receptor (Kis = 0.4 and >10 µM, respectively). AT2 agonist C21 (0.1 µM) induces neurite outgrowth in NG 108-15 cells. It reduces mean arterial blood pressure in anaesthetized spontaneously...
| Schlagworte: | Compound 21, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-carbamic acid, butyl ester |
| Anwendung: | AT2 receptor agonist |
| CAS | 477775-14-7 |
| MW: | 475.6 D |
ab 93,00 €
Anti-AGTR2
Artikelnummer: 600-401-X82
Anti-AGTR2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with AGTR2 from other sources has not been determined. Protein function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. [The UniProt Consortium]
| Schlagworte: | Anti-AT2, Anti-AGTR2, Anti-Type-2 angiotensin II receptor, Anti-Angiotensin II type-2 receptor |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
![2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine](https://www.biomol.com/media/image/da/42/a1/Cay17645-100_200x200.png "2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine")
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
Artikelnummer: Cay17645-250
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.Formal Name:...
| Schlagworte: | 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine |
| Anwendung: | Angiotensin II receptor antagonist |
| CAS | 133240-06-9 |
| MW: | 175.2 D |
ab 137,00 €
Angiotensin III (human, mouse)
Artikelnummer: Cay21618-10
Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells. Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine. Ang III induces the same...
| Schlagworte: | 5-L-isoleucine-2-8-angiotensin II |
| Anwendung: | AT1 / AT2 receptor agonist |
| CAS | 13602-53-4 |
| MW: | 931.1 D |
ab 49,00 €
Olmesartan Medoxomil
Artikelnummer: Cay11614-10
Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Cay-23412), a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2 receptor. Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces...
| Schlagworte: | CS 866,... |
| Anwendung: | Angiotensin II antagonist |
| CAS | 144689-63-4 |
| MW: | 558.6 D |
ab 49,00 €
Candesartan Celexetil Ester
Artikelnummer: LKT-C0254.250
| Schlagworte: | Candesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester |
| Anwendung: | Angiotenin II receptor antagonist |
| CAS | 145040-37-5 |
| MW: | 610,66 D |
ab 140,00 €
EMA401
Artikelnummer: Cay22988-1
EMA401 is an orally bioavailable and selective antagonist of the angiotensin II type 2 receptor (AT2, IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite...
| Schlagworte: | (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid |
| Anwendung: | Angiotensin II type 2 receptor antagonist |
| CAS | 1316755-16-4 |
| MW: | 507.6 D |
ab 84,00 €
Olmesartan Medoxomil-d6
Artikelnummer: Cay25759-1
Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil (Cay-11614) by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Cay-23412), a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1)...
| Schlagworte: | 4-(1-hydroxy-1-methylethyl-d6)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic... |
| Anwendung: | Angiotensin II antagonist, GC-MS, LC-MS, internal standard |
| CAS | 1127298-67-2 |
| MW: | 564.6 D |
ab 273,00 €
Anti-AGTR2
Artikelnummer: ARG57551.50
Protein function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. [The UniProt Consortium]
| Schlagworte: | Anti-AT2, Anti-AGTR2, Anti-Angiotensin II type-2 receptor, Anti-Type-2 angiotensin II receptor |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
625,00 €
Anti-AGTR2
Artikelnummer: ARG57550.100
Protein function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. [The UniProt Consortium]
| Schlagworte: | Anti-AT2, Anti-AGTR2, Anti-Angiotensin II type-2 receptor, Anti-Type-2 angiotensin II receptor |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
658,00 €
Saralasin (trifluoroacetate salt)
Artikelnummer: Cay32876-10
Saralasin is a peptide angiotensin II type 2 (AT2) receptor agonist. It binds to AT2 receptors (Ki = 0.38 nM) and induces neurite outgrowth in NG108-15 cells when used at a concentration at 100 nM, an effect that can be inhibited by the AT2 receptor antagonist PD 123310. Saralasin (5 µg/animal, i.c.v.) enhances...
| Schlagworte: | 1-Sar-8-Ala-Angiotensin II, Aralasin, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-alanine,... |
| Anwendung: | Peptide AT2 receptor agonist |
| MW: | 912.1 D |
ab 122,00 €