Paltusotine

An SST2 agonist, selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively), reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg, reduces plasma levels of IGF-1 in beagle dogs. Formulation: A solid. InChI: InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2. InChIKey: GHILNKWBALQPDP-UHFFFAOYSA-N. SMILES: N#CC1=C(O)C(C2=CC3=C(N4CCC(CC4)N)C(C5=CC(F)=CC(F)=C5)=CN=C3C=C2)=CC=C1