p,p'-DDD

p,p'-DDD is a metabolite of the organochlorine pesticide DDT. It is an agonist at estrogen receptor alpha (ERalpha) and ERbeta, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors. It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p'-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml. Blood levels of p,p'-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg).Formal Name: 1,1'-(2,2-dichloroethylidene)bis[4-chloro-benzene]. CAS Number: 72-54-8. Synonyms: 4,4'-DDD, 4,4'-Dichlorodiphenyldichloroethane, p,p-Dichlorodiphenyldichloroethane, NSC 8941. Molecular Formula: C14H10Cl4. Formula Weight: 320.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble. SMILES: ClC1=CC=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=C1. InChi Code: InChI=1S/C14H10Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8,13-14H. InChi Key: AHJKRLASYNVKDZ-UHFFFAOYSA-N.