Oxymatrine

White to off-white powder. Soluble in ethanol (25mg/ml), methanol, DMSO, DMF or water (all 10mg/ml). Chemical. CAS: 16837-52-8. Formula: C15H24N2O2. MW: 264.36. Isolated from plant source. Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-beta signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-kappaB. Neuroprotective by inhibition of apoptosis in neurons.