Oxprenolol (hydrochloride)

Oxprenolol is an orally bioavailable beta-adrenergic receptor (beta-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and binds to both beta1- and beta2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for beta-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.Formal Name: 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-2-propanol, monohydrochloride. CAS Number: 6452-73-9. Synonyms: dl-Alprenolol, dl-Oxprenolol. Molecular Formula: C15H23NO3 . HCl. Formula Weight: 301.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C=CCOC1=C(OCC(O)CNC(C)C)C=CC=C1.Cl. InChi Code: InChI=1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3,/h4-8,12-13,16-17H,1,9-11H2,2-3H3,1H. InChi Key: COAJXCLTPGGDAJ-UHFFFAOYSA-N.