OXOMEMAZINE

Description: Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. It is a selective antagonist of mycotoxins M1 receptors, exhibiting high (Ki=84 nM, M1 receptors) and low (Ki=1.65 µM, M2 receptors) affinity, with a 20-fold difference. Oxomemazine is an antihistamine and anticholinergic agent used in cough studies[1][2]. Target: GluR, AChR, Histamine Receptor. Smiles: CC(CN(C)C)CN1c2ccccc2S(=O)(=O)c2ccccc12. References: S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec,17(6):443-51.