OXA-01

OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively). It is selective for mTOR over PI3K isoforms and DNA protein kinase. OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.Formal Name: trans-4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid. CAS Number: 936889-68-8. Molecular Formula: C21H20ClN5O2. Formula Weight: 409.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/mL, DMSO: 3 mg/mL, DMSO:PBS(pH 7.2) (1:3): .25 mg/mL. lambdamax: 212, 336 nm. SMILES: OC([C@H]1CC[C@H](C2=NC(C3=CC4=C(C(Cl)=CC=C4)N3)=C5N2C=CN=C5N)CC1)=O. InChi Code: InChI=1S/C21H20ClN5O2/c22-14-3-1-2-13-10-15(25-16(13)14)17-18-19(23)24-8-9-27(18)20(26-17)11-4-6-12(7-5-11)21(28)29/h1-3,8-12,25H,4-7H2,(H2,23,24)(H,28,29)/t11-,12-. InChi Key: UXCAKZGNKOZXBM-HAQNSBGRSA-N.