Opipramol

Opipramol is a sigma-1 (sigma1) and sigma2 receptor ligand. It binds to sigma1 and sigma2 receptors in guinea pig brain membrane preparations (IC50s = 7 and 56 nM, respectively). It is selective for sigma1 and sigma2 over histamine H2, dopamine D1, alpha1- and alpha2-adrenergic, and muscarinic M1 receptors (IC50s = 4,300, 900, 200, 6,100, and 3,300 nM, respectively) and has no effect on serotonin (5-HT) or norepinephrine uptake (IC50s = >10,000 nM for both), but does bind to histamine H1 and dopamine D2 receptors (IC50s = 12 and 120 nM, respectively), as well as the 5-HT receptor subtype 5-HT2 (IC50 = 120 nM). Opipramol (0.01 mg/kg) increases social interaction time in a social exploration test in rats, indicating anxiolytic-like activity. It also decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg.Formal Name: 4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol. CAS Number: 315-72-0. Synonyms: G-33040, GR-33040, NSC 169867. Molecular Formula: C23H29N3O. Formula Weight: 363.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: slightly soluble, Chloroform: slightly soluble, Methanol: slightly soluble. lambdamax: 215, 257 nm. SMILES: OCCN(CC1)CCN1CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42. InChi Code: InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2. InChi Key: YNZFUWZUGRBMHL-UHFFFAOYSA-N.