NVS-ZP7-4

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7). It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin (Cay-17754) in MDA-MB-231 and RCC4 cells when used at a concentration of 10 µM.Formal Name: 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one. CAS Number: 2349367-89-9. Molecular Formula: C28H28FN5OS. Formula Weight: 501.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 227, 256 nm. SMILES: O=C1NC2(CCN(CC2)C[C@H](CC3=CC=CC=C3)NC4=NC5=CC=C(F)C=C5S4)C6=CC=CC=C6N1. InChi Code: InChI=1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1. InChi Key: FZOFDZMKSAUTHT-NRFANRHFSA-N.