NVP-BEZ235

NVP-BEZ235 is a dual inhibitor of class I PI3Ks (IC50s = 4, 75, 7, and 5 nM, for p110alpha, - beta, -delta, and -gamma, respectively) and mTOR (IC50 = 20 nM). It is selective for these enzymes over a panel of kinases (IC50s = >10 µM for all). NVP-BEZ235 (0.1 or 1 µM) inhibits proliferation of, and induces apoptosis in, MCF-7, MDA-MB-468, SK-BR-3, and MDA-MB-361 breast cancer cells. It reduces tumor growth in a U87MG mouse xenograft model when administered at a doses of 25, 35, or 45 mg/kg.Formal Name: 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile. CAS Number: 915019-65-7. Synonyms: Dactolisib. Molecular Formula: C30H23N5O. Formula Weight: 469.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 1 mg/ml. lambdamax: 266, 320 nm. SMILES: CC(C#N)(C)C(C=C1)=CC=C1N(C(N2C)=O)C3=C2C=NC4=CC=C(C5=CC(C=CC=C6)=C6N=C5)C=C43. InChi Code: InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3. InChi Key: JOGKUKXHTYWRGZ-UHFFFAOYSA-N.