NV03

NV03 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase UHRF1 (UHRF1) and histone H3 trimethylated lysine 9 (H3K9Me3). It binds the tandem Tudor domain (TTD) of UHRF1 (Kd = 2.4 µM) and is selective for the UHRF1-TTD over a panel of 36 demethylases at 10 µM.. SMILES: CC1=C2N(C3=C1SC=C3)C(C)=NN(C2=O)CC(NCCCN(CC)CC)=O. InChi Code: InChI=1S/C19H27N5O2S/c1-5-22(6-2)10-7-9-20-16(25)12-23-19(26)17-13(3)18-15(8-11-27-18)24(17)14(4)21-23/h8,11H,5-7,9-10,12H2,1-4H3,(H,20,25). InChi Key: KNZQAVKYBBYDKV-UHFFFAOYSA-N