Nitecapone

Nitecapone is a reversible inhibitor of S-catechol-O-methyltransferase (S-COMT, IC50 = 300 nM in rat liver). It is selective for S-COMT over tyrosine hydroxylase, dopamine-beta-hydroxylase, DOPA decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >1 µM for all). In vivo, nitecapone inhibits liver, duodenal, and brain S-COMT (ID50s = 5, 5, and 25 mg/kg, respectively). Nitecapone (3-30 mg/kg) reduces 3-O-methyl-DOPA (3-OMD) formation and increases serum and brain L-DOPA, dopamine, and DOPAC levels when administered in combination with L-DOPA (Cay-13248) and carbidopa (Cay-23783). Nitecapone (30 mg/kg) reduces mechanical and cold allodynia in a rat model of spinal nerve ligation-induced neuropathy.Formal Name: 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione. CAS Number: 116313-94-1. Synonyms: OR-462. Molecular Formula: C12H11NO6. Formula Weight: 265.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 225, 301 nm. SMILES: OC1=C([N+]([O-])=O)C=C(/C=C(C(C)=O)/C(C)=O)C=C1O. InChi Code: InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3. InChi Key: UPMRZALMHVUCIN-UHFFFAOYSA-N.