Zu "K00545" wurden 112 Artikel gefunden!
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Human COMT ELISA Kit
Artikelnummer: ARG81914.96
Protein function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. [The UniProt Consortium]
| Schlagworte: | COMT, Catechol O-methyltransferase |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.151,00 €
2-methoxy Estrone
Artikelnummer: Cay34155-50
2-methoxy Estrone is an active metabolite of the endogenous estrogen estrone (Cay-10006485). It is formed from estrone by catechol-O-methyltransferase (COMT). 2-methoxy Estrone inhibits the proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM). It increases the levels of 6-keto...
| Schlagworte: | 2-MeOE1, 2-methoxy E1, 3-hydroxy-2-methoxy-estra-1,3,5(10)-trien-17-one |
| Anwendung: | Estrone active metabolite |
| CAS | 362-08-3 |
| MW: | 300.4 D |
ab 92,00 €
Entacapone
Artikelnummer: Cay14153-10
Entacapone is a reversible catechol O-methyltransferase (COMT) inhibitor (IC50s = 10, 10, 20, and 160 nM for rat duodenum, brain, erythrocyte, and liver COMT, respectively). It is selective for COMT over monoamine oxidase A (MAO-A) and MAO-B and phenolsulphotransferase M (PST-M) and PST-P (IC50s = >50 µM)....
| Schlagworte: | OR-611, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2E-propenamide |
| Anwendung: | COMT inhibitor |
| CAS | 130929-57-6 |
| MW: | 305.3 D |
ab 53,00 €
Tolcapone
Artikelnummer: Cay20768-5
Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT, Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Cay-13248). Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity. By inhibiting...
| Schlagworte: | Ro 40-7592, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-methanone |
| Anwendung: | Reversible COMT inhibitor |
| CAS | 134308-13-7 |
| MW: | 273.2 D |
ab 57,00 €
3-methoxy Tyramine (hydrochloride)
Artikelnummer: Cay20511-100
3-methoxy Tyramine is a natural metabolite of dopamine, produced by catechol O-methyltransferase (COMT). It is a weak agonist of trace amine-associated receptor 1 (EC50 = 1.7 µM). 3-methoxy Tyramine levels are assessed to monitor COMT activity in Parkinson's disease. Elevated 3-methoxy Tyramine levels may also...
| Schlagworte: | 3-O-methyl Dopamine, 3-Methoxy-p-hydroxyphenethylamine, 3-Methoxy-4-hydroxyphenethylamine,... |
| Anwendung: | Dopamine metabolite |
| CAS | 1477-68-5 |
| MW: | 203.7 D |
ab 49,00 €
Metanephrine
Artikelnummer: Cay15408-10
Metanephrine is an inactive metabolite of epinephrine (Cay-21245). It is formed from epinephrine by catechol-O-methyl transferase (COMT). Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.Formal Name:...
| Schlagworte: | 4-hydroxy-3-methoxy-alpha-[(methylamino)methyl]-benzenemethanol |
| Anwendung: | Epinephrine COMT metabolite |
| CAS | 5001-33-2 |
| MW: | 197.2 D |
ab 93,00 €
Tolcapone-d4
Artikelnummer: Cay28697-1
Tolcapone-d4 is intended for use as an internal standard for the quantification of tolcapone (Cay-20768) by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT, Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine (Cay-21992) and...
| Schlagworte: | (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl-2,3,5,6-d4)methanone |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, Reversible COMT inhibitor |
| CAS | 1246816-93-2 |
| MW: | 277.3 D |
480,00 €
Purpurogallin
Artikelnummer: Cay29689-50
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Cay-20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S....
| Schlagworte: | NCI 35676, NSC 35676, NSC 646653, 2,3,4,6-tetrahydroxy-5H-benzocyclohepten-5-one |
| Anwendung: | Bioactive pyrogallol derivative |
| CAS | 569-77-7 |
| MW: | 220.2 D |
ab 57,00 €
Tolcapone
Artikelnummer: TGM-T6708-10mg
Description: Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor employed as an adjunctive therapy with levodopa and carbidopa in the treatment of Parkinson's disease. Target: Apoptosis, Transferase, Beta Amyloid. Smiles: C(=O)(C1=CC(N(=O)=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2. References: Zürcher G, et al....
| Schlagworte: | Ro 40-7592, Tasmar |
| Anwendung: | Targets catechol O-methyltransferase [EC:2.1.1.6] (COMT) |
| CAS | 134308-13-7 |
| MW: | 273.24 D |
ab 31,00 €
S-Catechol O-Methyltransferase (human, recombinant)
Artikelnummer: Cay15563-100
S-Catechol-O-methyltransferase (S-COMT) is the soluble cytosolic form of COMT. A rough endoplasmic reticulum membrane-bound form of COMT (MB-COMT) is also encoded by the COMT gene but produced via a separate promoter and contains an additional 50 amino acid residues, which compose the membrane anchor region. COMT is...
| Schlagworte: | Catechol O-methyltransferase {ECO:0000305}, Catechol O-methyltransferase {ECO:0000305} |
| Anwendung: | Enzyme activity |
| Ursprungsart: | human |
| MW: | 37.6 kD |
712,00 €
3-O-methyl-L-DOPA (hydrate)
Artikelnummer: Cay20737-10
3-O-methyl-L-DOPA is an active metabolite of L-DOPA (Cay-13248). It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-O-methyl-L-DOPA (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.Formal Name: 3-methoxy-L-tyrosine,...
| Schlagworte: | 3-methoxy DOPA, 3-OMD, 3-O-methyl-3,4-Dihydroxyphenylalanine, 3-methoxy-L-tyrosine, monohydrate |
| Anwendung: | COMT L-DOPA metabolite |
| CAS | 200630-46-2 |
| MW: | 229.2 D |
ab 38,00 €
3,5-Dinitrocatechol
Artikelnummer: Cay29180-1
3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM). It is selective for COMT over tyrosine hydroxylase, dopamine beta-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 µM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with...
| Schlagworte: | OR-486, 3,5-dinitro-1,2-benzenediol |
| Anwendung: | Potent COMT inhibitor |
| CAS | 7659-29-2 |
| MW: | 200.1 D |
ab 49,00 €