Nisoldipine-d6

Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine (Cay-20998) by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor. It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells. Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM). In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia. Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats. Formulations containing nisoldipine have been used in the treatment of hypertension.Formal Name: 3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. CAS Number: 1285910-03-3. Molecular Formula: C20H18D6N2O6. Formula Weight: 394.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble. SMILES: CC(NC(C)=C1C(OCC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2. InChi Code: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3/i1D3,2D3. InChi Key: VKQFCGNPDRICFG-WFGJKAKNSA-N.