Zu "K04850" wurden 89 Artikel gefunden!
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Verapamil (hydrochloride)
Artikelnummer: Cay14288-1
Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 =...
| Schlagworte: | NSC 272366, NSC 657799,... |
| Anwendung: | L-type Calcium channel blocker |
| CAS | 152-11-4 |
| MW: | 491.1 D |
49,00 €
Nifedipine
Artikelnummer: Cay11106-1
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 µM. Nifedipine (1 µM) reduces TGF-beta-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse...
| Schlagworte: | BAY 1040, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester |
| Anwendung: | Dihydropyridine calcium channel blocker |
| CAS | 21829-25-4 |
| MW: | 346.3 D |
ab 30,00 €
Nimodipine
Artikelnummer: Cay14573-500
Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels. It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM. Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in...
| Schlagworte: | BAY-e 9736, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl) 5-(1-methylethyl)... |
| Anwendung: | Ca2+ channel antagonist |
| CAS | 66085-59-4 |
| MW: | 418.4 D |
ab 54,00 €
Isradipine
Artikelnummer: Cay17536-10
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity. It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. By...
| Schlagworte: | PN 200-110, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl... |
| Anwendung: | L-type calcium channel blocker |
| CAS | 75695-93-1 |
| MW: | 371.4 D |
ab 67,00 €
Nisoldipine
Artikelnummer: Cay20998-100
Nisoldipine is a calcium channel inhibitor. It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells. Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM). In vivo, nisoldipine (3...
| Schlagworte: | (±)-BAY-K-5552, (±)-Nisoldipine, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl... |
| Anwendung: | CaV1.2 calcium channel blocker |
| CAS | 63675-72-9 |
| MW: | 388.4 D |
ab 40,00 €
Felodipine
Artikelnummer: Cay17535-5
Felodipine is an inhibitor of L-type calcium channels. It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels. Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the...
| Schlagworte: | H 154/82, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester |
| Anwendung: | L-type calcium channel blocker |
| CAS | 72509-76-3 |
| MW: | 384.3 D |
ab 49,00 €
FPL 64176
Artikelnummer: Cay20122-5
FPL 64176 is a nondihydropyridine that activates L-type Ca2+ channels with an EC50 value of 16 nM. It prolongs action potential duration and increases contractility in guinea pig atria preparations with an EC50 value of 49 nM.Formal Name: 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid, methyl...
| Schlagworte: | 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid, methyl ester |
| Anwendung: | Ca2+ channel activator |
| CAS | 120934-96-5 |
| MW: | 347.4 D |
ab 49,00 €
Amlodipine-d4 (maleate)
Artikelnummer: Cay25035-1
Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Cay-14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood...
| Schlagworte: | 2-[(2-aminoethoxy-1,1,2,2-d4)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid, 3-ethyl... |
| Anwendung: | Internal standard, GC-MS, LC-MS |
| CAS | 1185246-15-4 |
| MW: | 529 D |
ab 102,00 €
(S)-(-)-BAY-K-8644
Artikelnummer: Cay19988-500
(S)-(-)-BAY-K-8644 is an activator of voltage-sensitive L-type calcium channels. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. When combined with BIX01294 (Cay-13124), (S)-(-)-BAY-K-8644 can enable reprogramming of mouse...
| Schlagworte: | (4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester |
| Anwendung: | Voltage-sensitive L-type calcium channel activator |
| CAS | 98625-26-4 |
| MW: | 356.3 D |
ab 49,00 €
Bepridil (hydrochloride)
Artikelnummer: Cay19645-10
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4)...
| Schlagworte: | beta-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride |
| Anwendung: | Calcium channel blocker |
| CAS | 68099-86-5 |
| MW: | 403 D |
ab 49,00 €
Nisoldipine
Artikelnummer: LKT-N3474.50
Calcium channel blocker.
| Anwendung: | Calcium channel L type blocker |
| CAS | 63675-72-9 |
| MW: | 388.42 D |
ab 80,00 €
Manidipine
Artikelnummer: Cay23614-10
Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (alpha1Calpha2/deltabeta1a) and human T-type (alpha1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine...
| Schlagworte: | (±)-Manidipine, CV-4093, Franidipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid,... |
| Anwendung: | L-type / T-type calcium channel blocker |
| CAS | 89226-50-6 |
| MW: | 610.7 D |
ab 163,00 €