Nisoldipine

Nisoldipine is a calcium channel inhibitor. It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells. Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM). In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia. Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats. Formulations containing nisoldipine have been used in the treatment of hypertension.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-(2-methylpropyl) ester. CAS Number: 63675-72-9. Synonyms: (±)-BAY-K-5552, (±)-Nisoldipine. Molecular Formula: C20H24N2O6. Formula Weight: 388.4. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 3 mg/ml. lambdamax: 235, 330 nm. SMILES: CC(N([H])C(C)=C1C(OCC(C)C)=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2. InChi Code: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3. InChi Key: VKQFCGNPDRICFG-UHFFFAOYSA-N.