Nimorazole

Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities. It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 µM). Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg). Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.Formal Name: 4-[2-(5-nitro-1H-imidazol-1-yl)ethyl]-morpholine. CAS Number: 6506-37-2. Synonyms: Acterol, Naxofem, Naxogin, Nitrimidazine, NSC 107524. Molecular Formula: C9H14N4O3. Formula Weight: 226.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:3): 0.25mg/mL, DMSO: 10mg/mL, Ethanol: 2mg/mL. SMILES: O=[N+](C1=CN=CN1CCN2CCOCC2)[O-]. InChi Code: InChI=1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2. InChi Key: MDJFHRLTPRPZLY-UHFFFAOYSA-N.