NIBR17

NIBR17 is an inhibitor of PI3Kalpha (IC50 = 50s = 0.09 and 0.73 µM, respectively). NIBR17 (60 mg/kg) reduces tumor volume in an A2780 mouse xenograft model.Formal Name: N6-(6-methoxy-3-pyridinyl)-2-(4-morpholinyl)-[4,5'-bipyrimidine]-2',6-diamine. CAS Number: 944396-88-7. Molecular Formula: C18H20N8O2. Formula Weight: 380.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 3 mg/ml. lambdamax: 273, 334 nm. SMILES: NC1=NC=C(C2=CC(NC3=CN=C(C=C3)OC)=NC(N4CCOCC4)=N2)C=N1. InChi Code: InChI=1S/C18H20N8O2/c1-27-16-3-2-13(11-20-16)23-15-8-14(12-9-21-17(19)22-10-12)24-18(25-15)26-4-6-28-7-5-26/h2-3,8-11H,4-7H2,1H3,(H2,19,21,22)(H,23,24,25). InChi Key: XZTYTIOLZIKUJR-UHFFFAOYSA-N.