Nesuparib

Description: Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatment of tumors, endocrine and metabolic disorders, genitourinary disorders, and can be used in the study of neuropathic pain, neurodegenerative disorders, and cardiovascular diseases. Target: Wnt/beta-catenin, PARP. Smiles: O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(cn3)C#N)ccc2c2NCCCc12. References: Hyunho Lee, et al. Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same. WO2016200101A2.