Nerolidol

Nerolidol is a sesquiterpene found in a variety of plants, including C. sativa, that has diverse biological activities, including antioxidant, anthelmintic, antinociceptive, and anti-inflammatory properties. It decreases superoxide dismutase (SOD) and catalase activity, reduces glutathione (GSH) levels, and increases malondialdehyde (MDA) levels in the brain when administered at a dose of 50 mg/kg in a rat model of Parkinson's disease induced by rotenone (Cay-13995). It also inhibits rotenone-induced increases in IL-1beta, IL-6, and TNF-alpha in rat brain. Nerolidol (100, 200, and 400 mg/kg) reduces worm burden and egg production in a mouse model of schistosomiasis. It also decreases acetic acid-induced writhing and formalin-induced licking time in mice, indicating antinociceptive activity, and reduced carrageenan-induced paw edema when administered at doses of 300 and 400 mg/kg. Formulations containing nerolidol have been used as fragrance ingredients.Formal Name: 3,7,11-trimethyl-1,6,10-dodecatrien-3-ol. CAS Number: 7212-44-4. Synonyms: (±)-Nerolidol. Molecular Formula: C15H26O. Formula Weight: 222.4. Purity: >95%. Formulation: (Request formulation change), An oil. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: C=CC(O)(C)CC/C=C(C)/CC/C=C(C)/C. InChi Code: InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11+. InChi Key: FQTLCLSUCSAZDY-SDNWHVSQSA-N.