Neoruscogenin

Neoruscogenin is a natural sapogenin isolated from Butcher's broom (R. rhizoma), which is traditionally used against chronic venous disorders. It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORalpha (EC50 = 110 nM). In mice, neoruscogenin up-regulates the expression of several RORalpha-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.Formal Name: spirosta-5,25(27)-diene-1beta,3beta-diol. CAS Number: 17676-33-4. Synonyms: 25(27)-Dehydroruscogenin. Molecular Formula: C27H40O4. Formula Weight: 428.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. SMILES: C=C(CO1)CC[C@@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C. InChi Code: InChI=1S/C27H40O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,16,18-24,28-29H,1,6-14H2,2-4H3/t16-,18+,19+,20-,21-,22-,23+,24-,25-,26-,27+/m0/s1. InChi Key: ALTRINCJVPIQNK-NHIXJPGBSA-N.