Nebivolol (hydrochloride)

Nebivolol is an antagonist of the beta1-adrenergic receptor (beta1-AR, IC50 = 7.41 nM). It is selective for beta1- over beta2-ARs (IC50 = 251 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 and the alpha1- and alpha2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5, 2,239, 3,162, >10,000, 5,623, and 10,000 nM, respectively). Nebivolol induces vasodilation in isolated mouse renal arteries (EC50 = 11.36 µM) and decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (Cay-15592, IC50 = 7 µM). Nebivolol inhibits proliferation of primary human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 µM for HCASMCs grown in media containing no growth factor, PDGF-BB, basic FGF, and TGF-beta1, respectively). It is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro, IC50 = 60.2 µg/ml), and inhibits SARS-CoV-2 pathogenicity in vitro (IC50 = 0.03 µg/ml). Formulations containing nebivolol have been used in the treatment of hypertension.Formal Name: (alphaR,alpha'R,2R,2'S)-rel-alpha,alpha'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol, monohydrochloride. CAS Number: 152520-56-4. Molecular Formula: C22H25F2NO4 . HCl. Formula Weight: 441.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 281 nm. SMILES: FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1.Cl. InChi Code: InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22,/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2,1H/t17-,18-,21-,22+,/m0./s1. InChi Key: JWEXHQAEWHKGCW-BIISKSHESA-N.