Naftifine hydrochloride

Description: Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. Target: Antibiotic, Antifungal, Hedgehog/Smoothened. Smiles: Cl.CN(C\C=C\c1ccccc1)Cc1cccc2ccccc12. References: Georgopoulos A, et al. Antimicrob Agents Chemother, 1981, 19(3), 386-389.