NAB 2

NAB 2 is an inhibitor of alpha-synuclein-induced toxicity. It prevents alpha-synuclein-induced defects in Rsp5-dependent endocytosis and vacuolar delivery of Mup1, Golgi-to-vacuole trafficking of Sna3, and degradation of Bap2 in wild-type yeast cells. NAB 2 also prevents formation of alpha-synuclein foci in wild-type yeast cells, an effect that is prevented by the rsp5G747E point mutation.Formal Name: N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide. CAS Number: 1504588-00-4. Molecular Formula: C23H20ClN3O. Formula Weight: 389.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/mL. lambdamax: 220 nm. SMILES: ClC1=C(CNC(C2=CC=C(N(C3=C(C)C=CC(C)=C3)C=N4)C4=C2)=O)C=CC=C1. InChi Code: InChI=1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12,14H,13H2,1-2H3,(H,25,28). InChi Key: CZSLEMCYYGEGKP-UHFFFAOYSA-N.