N-Oleoyl Leucine

N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model. It improves glucose homeostasis in a fasting glucose tolerance test and increases VO2 while slightly decreasing overall locomotor activity.Formal Name: N-[(9Z)-1-oxo-9-octadecen-1-yl]-L-leucine. CAS Number: 136560-76-4. Molecular Formula: C24H45NO3. Formula Weight: 395.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 12 mg/ml, Ethanol: 12 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 200 µg/ml. lambdamax: 272 nm. SMILES: CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC(C)C)C(O)=O)=O. InChi Code: InChI=1S/C24H45NO3/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)25-22(24(27)28)20-21(2)3/h11-12,21-22H,4-10,13-20H2,1-3H3,(H,25,26)(H,27,28)/b12-11-/t22-/m0/s1. InChi Key: UMOAAMQGRRCHPA-GJCOWUBNSA-N.