MZ 1

Description: MZ 1 is a BRD4 protein degrader based on PROTAC technology. Target: Epigenetic Reader Domain, PROTACs. Smiles: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCO CC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C. References: Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 201. May,13(5):514-521.