Mycophenolic Acid beta-D-Glucuronide

Mycophenolic acid beta-D-glucuronide (MPAG) is a metabolite of the immunosuppressant mycophenolic acid (Cay-21716). It is formed from mycophenolic acid by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A8, UGT1A7, and UGT1A10 in insect cell-derived supersomes expressing the human enzymes. Unlike mycophenolic acid, MPAG does not inhibit IMP dehydrogenase (IMPDH) type II in a cell-free assay. However, it does reduce tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at a dose of 6 mg/animal.Formal Name: 5-[(2E)-5-carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl beta-D-glucopyranosiduronic acid. CAS Number: 31528-44-6. Synonyms: MPAG, MPA-phenyl-glucuronide, Mycophenolic Acid Glucosiduronate. Molecular Formula: C23H28O12. Formula Weight: 496.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 214, 250, 292 nm. SMILES: O=C1OCC2=C(C)C(OC)=C(C/C=C(C)/CCC(O)=O)C(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=C21. InChi Code: InChI=1S/C23H28O12/c1-9(5-7-13(24)25)4-6-11-18(32-3)10(2)12-8-33-22(31)14(12)19(11)34-23-17(28)15(26)16(27)20(35-23)21(29)30/h4,15-17,20,23,26-28H,5-8H2,1-3H3,(H,24,25)(H,29,30)/b9-4+/t15-,16-,17+,20-,23+/m0/s1. InChi Key: BYFGTSAYQQIUCN-HGIHDBQLSA-N.