Zu "K00088" wurden 67 Artikel gefunden!
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Human IMPDH2 (Inosine 5'-Monophosphate Dehydrogenase 2)...
Artikelnummer: ELK-ELK4812.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IMPDH2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IMPDH2....
| Schlagworte: | IMPD2, IMPD 2, IMPDH 2, IMPDH-II, IMP dehydrogenase 2, IMP dehydrogenase II, Inosine-5'-monophosphate dehydrogenase 2,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Mycophenolic Acid (CRM)
Artikelnummer: Cay39477-1
Mycophenolic acid (CRM) (Cay-39477) is a certified reference material categorized as an immunosuppressive mycotoxin. Mycophenolic acid has been found as a contaminant in cereal grain dusts. Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant...
| Schlagworte: | MPA, NSC 129185, (4E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid |
| Anwendung: | Certified reference material, immunosuppr. mycotoxin, inosine monophosphate dehydrogenase inhibitor |
| CAS | 24280-93-1 |
| MW: | 320.3 D |
96,00 €
Xanthosine 5'-monophosphate (sodium salt)
Artikelnummer: Cay18134-10
Xanthosine 5'-monophosphate (XMP) is an intermediate in purine metabolism, the product of the rate limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. XMP is generated from inosine-5'-monophosphate (IMP, Cay-18135) by IMP dehydrogenase (IMPDH)....
| Schlagworte: | XMP, 5'-xanthylic acid, disodium salt |
| Anwendung: | IMP dehydrogenase (IMPDH) metabolite |
| CAS | 25899-70-1 |
| MW: | 408.2 D |
ab 43,00 €
Mycophenolic Acid
Artikelnummer: Cay21716-25
Mycophenolic acid is an immunosuppresive microbial metabolite that has been found in P. brevicompactum. It is also an active metabolite of mycophenolate mofetil (Cay-13988) that is formed via carboxylesterase 1 (CES1) and CES2. Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s...
| Schlagworte: | MPA, NSC 129185, (4E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid |
| Anwendung: | Inosine monophosphate dehydrogenase inhibitor |
| CAS | 24280-93-1 |
| MW: | 320.3 D |
ab 50,00 €
Anti-Inosine-5'-monophosphate dehydrogenase 2 / IMPDH2
Artikelnummer: NSJ-RQ7329
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining...
| Schlagworte: | Anti-IMPD2, Anti-IMPD 2, Anti-IMPDH 2, Anti-IMPDH-II, Anti-IMP dehydrogenase 2, Anti-IMP dehydrogenase II,... |
| Anwendung: | WB, IHC (paraffin), FC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
COVID-19 Forschung
Ribavirin
Artikelnummer: AG-CR1-3719-M050
Soluble in DMSO (15mg/ml) or DMF (15mg/ml). Ribavirin is a guanosine analog with broad-spectrum antiviral properties against DNA and RNA viruses, including coronavirus SARS, respiratory syncytial virus, several hemorrhagic fever viruses, hepatitis C (HCV) and influenza. It is also tested for SARS-CoV-2. It acts as...
| Schlagworte: | NSC 163039, Rebetol, Ribasphere, Virazole, Copegus, 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide |
| Anwendung: | Arabinofuranosyl type antiviral, Guanosine analog |
| CAS | 36791-04-5 |
| MW: | 244.2 D |
ab 22,00 €
Inosine-5'-monophosphate (sodium salt hydrate)
Artikelnummer: Cay18135-5
Inosine-5'-monophosphate (IMP) is a substrate of IMP dehydrogenase (IMPDH), a NAD+-dependent enzyme that generates xanthosine monophosphate. This is a rate-limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. Inhibitors of IMPDH, including ribavirin...
| Schlagworte: | IMP, Inosinic Acid, 5'-Inosinic acid, disodium salt octahydrate |
| Anwendung: | IMP dehydrogenase (IMPDH) substrate |
| CAS | 20813-76-7 |
| MW: | 536.3 D |
ab 43,00 €
Ribavirin 5'-monophosphate (lithium salt)
Artikelnummer: Cay21821-5
Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin (Cay-16757),...
| Schlagworte: | 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, dilithium salt |
| Anwendung: | Antiviral, IMPDH inhibitor |
| CAS | 66983-94-6 |
| MW: | 336.1 D |
ab 77,00 €
Mycophenolate Mofetil
Artikelnummer: Cay13988-50
Mycophenolate mofetil is a prodrug form of mycophenolic acid (Cay-21716). It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2. Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells. In vivo, mycophenolate mofetil (12.5 mg/kg)...
| Schlagworte: | MMF, RS 61443, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid,... |
| Anwendung: | Immunosuppressive compound, IMP dehydrogenase inhibitor |
| CAS | 128794-94-5 |
| MW: | 433.5 D |
ab 61,00 €
Mycophenolic Acid beta-D-Glucuronide
Artikelnummer: Cay19078-1
Mycophenolic acid beta-D-glucuronide (MPAG) is a metabolite of the immunosuppressant mycophenolic acid (Cay-21716). It is formed from mycophenolic acid by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A8, UGT1A7, and UGT1A10 in insect cell-derived supersomes expressing the human enzymes. Unlike...
| Schlagworte: | MPAG, Mycophenolic Acid Glucosiduronate,... |
| Anwendung: | Mycophenolic acid metabolite, Internal standard |
| CAS | 31528-44-6 |
| MW: | 496.5 D |
ab 161,00 €
Mizoribine
Artikelnummer: Cay23128-10
Mizoribine is an imidazole nucleoside with immunosuppressive properties. It inhibits T cell proliferation in response to various mitogenic stimuli by 10-100% when used at concentrations ranging from 1 to 50 µg/mL. Mizoribine inhibits proliferation of stimulated T cells (IC50 = 5 µg/ml), which can be reversed by...
| Schlagworte: | NSC 289637, 5-hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| Anwendung: | IMPDH inhibitor, Antiinflammatory |
| CAS | 50924-49-7 |
| MW: | 259.2 D |
ab 54,00 €
Merimepodib
Artikelnummer: Cay29351-5
Merimepodib is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH, Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells...
| Schlagworte: | VX-497, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-carbamic acid,... |
| Anwendung: | IMPDH inhibitor |
| CAS | 198821-22-6 |
| MW: | 452.5 D |
ab 43,00 €