Muraglitazar

Description: Muraglitazar (BMS-298585) is a PPAR alpha/gamma dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARalpha and PPARgamma with EC50 of 320 nM and 110 nM respectively. Target: PPAR. Smiles: C(COC1=CC=C(CN(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4. References: Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005,27(8):1181-1195.