MRT67307 (hydrochloride)

MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKepsilon, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs, IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively). MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-beta and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formal Name: N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide, hydrochloride. Molecular Formula: C26H36N6O2 . XHCl. Formula Weight: 464.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 3 mg/ml, Ethanol: 2 mg/ml. lambdamax: 271 nm. SMILES: O=C(C1CCC1)NCCCNC2=NC(NC3=CC(CN4CCOCC4)=CC=C3)=NC=C2C5CC5.Cl. InChi Code: InChI=1S/C26H36N6O2.ClH/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32,/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31),1H. InChi Key: YBZGSNFTJJTIIO-UHFFFAOYSA-N.