MRT-2359

Description: MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits preferential activity in MYC-driven cell lines. Target: Apoptosis, Others. Smiles: O=C1N(CC=2C1=CC(COC(NC3=CC(OC(F)(F)F)=CC=C3F)=O)=CC2)C4C(=O)NC(=O)CC4. References: Gerald Gavory, et al. Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction. Cancer Res. 2023 , 83(7): 3449.