Mps1-IN-1

Mps1-IN-1 is a selective inhibitor of monopolar spindle 1 (Mps1) kinase (IC50 = 367 nM), a dual-specificity kinase involved in spindle assembly checkpoint and the maintenance of chromosomal stability. It exhibits greater than 1,000-fold selectivity against a panel of 352 kinases. Mps1-IN-1 has been shown to disrupt the recruitment of Mad2 to kinetochores and to increase the frequency of multipolar mitosis in U2OS cells.Formal Name: 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol. CAS Number: 1125593-20-5. Synonyms: Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1. Molecular Formula: C28H33N5O4S. Formula Weight: 535.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMF:PBS (pH 7.2) (1:9): 0.1 mg/mL, DMSO: 30 mg/mL. lambdamax: 295 nm. SMILES: COC1=C(NC2=CC(NC3=CC=CC=C3S(C(C)C)(=O)=O)=C(C=CN4)C4=N2)C=CC(N5CCC(O)CC5)=C1. InChi Code: InChI=1S/C28H33N5O4S/c1-18(2)38(35,36)26-7-5-4-6-23(26)30-24-17-27(32-28-21(24)10-13-29-28)31-22-9-8-19(16-25(22)37-3)33-14-11-20(34)12-15-33/h4-10,13,16-18,20,34H,11-12,14-15H2,1-3H3,(H3,29,30,31,32). InChi Key: NMJMRSQTDLRCRQ-UHFFFAOYSA-N.