Mobocertinib

Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors. It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310F over wild-type EGFR in Ba/F3 cells.Formal Name: 2-[[4-[[2-(dimethylamino)ethyl]methylamino]-2-methoxy-5-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-4-(1-methyl-1H -indol-3-yl)-5-pyrimidinecarboxylic acid, 1-methylethyl ester. CAS Number: 1847461-43-1. Synonyms: AP32788, TAK-788. Molecular Formula: C32H39N7O4. Formula Weight: 585.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml. SMILES: O=C(C1=C(C2=CN(C)C3=C2C=CC=C3)N=C(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)N=C1)OC(C)C. InChi Code: InChI=1S/C32H39N7O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36). InChi Key: AZSRSNUQCUDCGG-UHFFFAOYSA-N.