MNI137

MNI137 is a negative allosteric modulator of metabotropic glutamate receptor 2 (mGluR2). It selectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing human mGluR2 (IC50 = 11.4 nM) over HEK293 cells expressing rat mGluR1, -5, -7, or -8 and those expressing human mGluR4 at 10 µM.. SMILES: N#CC1=CC(C2=NC(C=CC(Br)=C3)=C3NC(C2)=O)=CC=N1. InChi Code: InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21). InChi Key: KMKZCMKOSAKVGY-UHFFFAOYSA-N