MN-64

Tankyrases (TNKS) are poly-ADP-ribosyltransferases, which cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. MN-64 is a potent inhibitor of TNKS1 and TNKS2 (IC50s = 6 and 72 nM, respectively). It is ineffective against several poly(ADP-ribosyl) polymerases (IC50 > 19 µM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/beta-catenin pathway in a cell-based reporter assay.Formal Name: 2-[4-(1-methylethyl)phenyl]-4H-1-benzopyran-4-one. CAS Number: 92831-11-3. Molecular Formula: C18H16O2. Formula Weight: 264.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 30 mg/ml. lambdamax: 255, 300 nm. SMILES: O=C1C2=CC=CC=C2OC(C3=CC=C(C(C)C)C=C3)=C1. InChi Code: InChI=1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3. InChi Key: PYTOHIUBXSJKQH-UHFFFAOYSA-N.