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Anti-Tankyrase 1
Anti-Tankyrase 1

Artikelnummer: A302-398A

Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction...
Schlagworte: Anti-TNKS, Anti-ARTD5, Anti-TANK1, Anti-TNKS-1, Anti-PARP5A, EC=2.4.2.30, Anti-Tankyrase-1, Anti-Tankyrase I, Anti-Poly...
Anwendung: IP
Reaktivität: Human
ab 125,00 €
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XAV939
XAV939

Artikelnummer: Cay13596-1

The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector beta-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the...
Schlagworte: 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Anwendung: TNKS inhibitor
CAS 284028-89-3
MW: 312.3 D
ab 13,00 €
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PJ-34 (hydrochloride)
PJ-34 (hydrochloride)

Artikelnummer: Cay14440-5

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. PJ-34 is an inhibitor of PARPs which can be used in cells or in animals. It binds and inhibits the PARP tankyrase1 (IC50 = 1 µM). PJ-34 also...
Schlagworte: N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-acetamide, monohydrochloride
Anwendung: PARP inhibitor
CAS 344458-15-7
MW: 331.8 D
ab 37,00 €
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Anti-Tankyrase (TRF1-interacting Ankyrin-related ADP-ribose Polymerase, Tankyrase TRF1-interacting A
Anti-Tankyrase (TRF1-interacting Ankyrin-related...

Artikelnummer: T0900-20B.100

Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length...
Schlagworte: EC=2.4.2.30, Anti-Poly [ADP-ribose] polymerase 5A, Anti-TRF1-interacting ankyrin-related ADP-ribose polymerase
Anwendung: ELISA, IHC, WB
Reaktivität: Human
679,00 €
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Anti-Tankyrase 1
Anti-Tankyrase 1

Artikelnummer: A302-399A-T

Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction...
Schlagworte: Anti-TNKS, Anti-ARTD5, Anti-TANK1, Anti-TNKS-1, Anti-PARP5A, EC=2.4.2.30, Anti-Tankyrase-1, Anti-Tankyrase I, Anti-Poly...
Anwendung: WB, IP, IHC
Reaktivität: Human
ab 125,00 €
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Human TNKS1 (Tankyrase 1) CLIA Kit
Human TNKS1 (Tankyrase 1) CLIA Kit

Artikelnummer: G-HUES01260.96

ELISA Type: CLIA. Sensitivity: 37.5 pg/mL. Range: 62.5--4000 pg/mL. Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114,...
Schlagworte: ARTD5, TANK1, TNKS-1, Tankyrase-1, Tankyrase I, Poly [ADP-ribose] polymerase 5A, Poly [ADP-ribose] polymerase tankyrase-1,...
Anwendung: CLIA
Reaktivität: Human
629,00 €
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Human TNKS2 (Tankyrase 2) CLIA Kit
Human TNKS2 (Tankyrase 2) CLIA Kit

Artikelnummer: G-HUES01261.96

ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245,...
Schlagworte: ARTD6, TANK2, TNKS-2, Tankyrase-2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, Poly [ADP-ribose]...
Anwendung: CLIA
Reaktivität: Human
629,00 €
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Human TNKS1 (Tankyrase 1) ELISA Kit
Human TNKS1 (Tankyrase 1) ELISA Kit

Artikelnummer: G-HUES03287.96

ELISA Type: Sandwich. Sensitivity: 0.188ng/mL. Range: 0.313--20ng/mL. Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859,...
Schlagworte: ARTD5, TANK1, TNKS-1, Tankyrase-1, Tankyrase I, Poly [ADP-ribose] polymerase 5A, Poly [ADP-ribose] polymerase tankyrase-1,...
Anwendung: Sandwich ELISA
Reaktivität: Human
566,00 €
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Human TNKS2 (Tankyrase 2) ELISA Kit
Human TNKS2 (Tankyrase 2) ELISA Kit

Artikelnummer: G-HUES03288.96

ELISA Type: Sandwich. Sensitivity: 0.094ng/mL. Range: 0.156--10ng/mL. Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245,...
Schlagworte: ARTD6, TANK2, TNKS-2, Tankyrase-2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, Poly [ADP-ribose]...
Anwendung: Sandwich ELISA
Reaktivität: Human
566,00 €
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Tankyrase 1 (PARP5A), active human recombinant protein, N-terminal GST tag
Tankyrase 1 (PARP5A), active human recombinant protein,...

Artikelnummer: BPS-80504

TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), a.a. 1000-1328(end), with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a baculovirus expression system. Autoribosylation reaction is conducted in wells...
Schlagworte: TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1, TANK1, Tankyrase-1, EC=2.4.2.30, TNKS-1, Tankyrase I, Poly [ADP-ribose]...
Anwendung: Enzyme kinetics, inhibitor screening, Selectivity profiling
Reaktivität: Human
MW: 62.5 kD
618,00 €
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G007-LK
G007-LK

Artikelnummer: Cay22934-1

G007-LK is an inhibitor of the tankyrases TNKS1 and TNKS2 (IC50s = 46 and 25 nM, respectively). It is selective for TNKS1 and TNKS2 over a panel of 90 kinases, 16 phosphatases, and 73 G protein-coupled receptors (GPCRs) when used at a concentration of 10 µM. G007-LK inhibits colony formation of COLO 320 DM and SW403...
Schlagworte: Tankyrase 1/2 Inhibitor VI,...
Anwendung: TNKS / TNKS2 inhibitor
CAS 1380672-07-0
MW: 530 D
ab 32,00 €
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XAV-939
XAV-939

Artikelnummer: LKT-X0384.25

Tankyrase inhibitor.
Schlagworte: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
Anwendung: Tankyrase inhibitor
CAS 284028-89-3
MW: 312.31 D
ab 71,00 €
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