Zu "K10799" wurden 91 Artikel gefunden!
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NEU
M2912
Artikelnummer: Cay45586-1
M2912 is an inhibitor of tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.6 and 0.9 nM, respectively). It is selective for TNKS1 and TNKS2 over poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 928 nM). M2912 increases the levels of Axin2 (EC50 = 17 nM) and reduces Wnt reporter activity in DLD-1 cells. It reduces the growth of a...
| Schlagworte: | MSC2504877, 3-[4-(1-hydroxy-1-methylethyl)phenyl]-6-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one |
| Anwendung: | TNKS1/2 inhibitor |
| CAS | 1460286-21-8 |
| MW: | 282.34 D |
ab 49,00 €
TNKS-1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-04065-100ug
Description: TNKS-1 Protein, Human, Recombinant (His) is expressed in E. coli with C-6xHis. The accession number is O95271.
| Schlagworte: | TNKS1 , Poly [ADP-ribose] polymerase tankyrase-1 , TNKS , TIN1 , PARPL , TNKS-1 , TINF1 , Tankyrase-1 (TANK1) , Poly... |
| MW: | 91.9 kD |
ab 93,00 €
Nesuparib
Artikelnummer: Cay45304-1
A dual PARP1/2 and TNKS1/2 inhibitor, reduces the proliferation of Capan-1 PDAC cells (IC50 = 0.1895 µM), selectively inhibits the proliferation of, and induces apoptosis and G2/M phase cell cycle arrest in, HPAF-II and AsPC-1 PDAC cells expressing RNF43 loss-of-function mutations over SNU-410 PDAC cells expressing...
| Schlagworte: | JPI-547, 6-[4-[(1,2,3,4,5,6-hexahydro-5-oxobenzo[h]-1,6-naphthyridin-8-yl)methyl]-1-piperazinyl]-3-pyridinecarbonitrile |
| Anwendung: | Dual PARP1/2 / TNKS1/2 inhibitor |
| CAS | 2055357-64-5 |
| MW: | 400.49 D |
ab 78,00 €
XAV939
Artikelnummer: Cay13596-1
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector beta-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the...
| Schlagworte: | 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Anwendung: | TNKS inhibitor |
| CAS | 284028-89-3 |
| MW: | 312.3 D |
ab 40,00 €
Anti-Tankyrase 1
Artikelnummer: A302-398A
Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction...
| Schlagworte: | Anti-TNKS, Anti-ARTD5, Anti-TANK1, Anti-TNKS-1, Anti-PARP5A, EC=2.4.2.30, Anti-Tankyrase-1, Anti-Tankyrase I, Anti-Poly... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
PJ-34 (hydrochloride)
Artikelnummer: Cay14440-5
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. PJ-34 is an inhibitor of PARPs which can be used in cells or in animals. It binds and inhibits the PARP tankyrase1 (IC50 = 1 µM). PJ-34 also...
| Schlagworte: | N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-acetamide, monohydrochloride |
| Anwendung: | PARP inhibitor |
| CAS | 344458-15-7 |
| MW: | 331.8 D |
ab 58,00 €
Anti-Tankyrase 1
Artikelnummer: A302-399A-T
Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction...
| Schlagworte: | Anti-TNKS, Anti-ARTD5, Anti-TANK1, Anti-TNKS-1, Anti-PARP5A, EC=2.4.2.30, Anti-Tankyrase-1, Anti-Tankyrase I, Anti-Poly... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Tankyrase 1 (PARP5A), active human recombinant protein,...
Artikelnummer: BPS-80504
TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), a.a. 1000-1328(end), with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a baculovirus expression system. Autoribosylation reaction is conducted in wells...
| Schlagworte: | ARTD5, TANK1, TNKS-1, Tankyrase-1, Tankyrase I, Poly [ADP-ribose] polymerase 5A, Poly [ADP-ribose] polymerase tankyrase-1,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 62.5 kD |
775,00 €
Tankyrase 2 (PARP5b) Active Human Recombinant Protein
Artikelnummer: BPS-80505
TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B/C, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235), a.a. 667-1166(end), with N-terminal GST-tag, MW=80.5 kDa, expressed in Sf9 cells via a baculovirus expressio
| Schlagworte: | TANK2, ARTD6, TNKS-2, Tankyrase-2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, Poly [ADP-ribose]... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 80.5 kD |
775,00 €
XAV-939
Artikelnummer: LKT-X0384.5
Tankyrase inhibitor.
| Schlagworte: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol |
| Anwendung: | Tankyrase inhibitor |
| CAS | 284028-89-3 |
| MW: | 312.31 D |
ab 98,00 €
G007-LK
Artikelnummer: Cay22934-1
G007-LK is an inhibitor of the tankyrases TNKS1 and TNKS2 (IC50s = 46 and 25 nM, respectively). It is selective for TNKS1 and TNKS2 over a panel of 90 kinases, 16 phosphatases, and 73 G protein-coupled receptors (GPCRs) when used at a concentration of 10 µM. G007-LK inhibits colony formation of COLO 320 DM and SW403...
| Schlagworte: | Tankyrase 1/2 Inhibitor VI,... |
| Anwendung: | TNKS / TNKS2 inhibitor |
| CAS | 1380672-07-0 |
| MW: | 530 D |
ab 51,00 €
JW55
Artikelnummer: LKT-J8800.1
TNKS1/2 inhibitor.
| Anwendung: | TNKS1/2 inhibitor |
| CAS | 664993-53-7 |
| MW: | 434.49 D |
ab 104,00 €