ML-SA1

ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Cay-20425) prior to isolation from HEK293 cells expressing TRPML1. It also activates whole-endolysosome IML1 in primary murine macrophages.Formal Name: 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione. CAS Number: 332382-54-4. Synonyms: Mucolipin synthetic agonist 1. Molecular Formula: C22H22N2O3. Formula Weight: 362.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 216 nm. SMILES: CC1(C)CC(C)C2=CC=CC=C2N1C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O. InChi Code: InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3. InChi Key: KDDHBJICVBONAX-UHFFFAOYSA-N.