Zu "K04992" wurden 19 Artikel gefunden!
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ML-SA5
Artikelnummer: TGM-T60036-100mg
Description: ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. Target: Autophagy. Smiles: CN(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(Cl)c1N1CCCCC1. References: Qi J, et al. MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc...
| Anwendung: | TRPML1 agonist |
| CAS | 2418670-70-7 |
| MW: | 457.99 D |
ab 34,00 €
Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01710-100ug
Description: Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 66.5 kDa and the accession number is Q9GZU1.
| Schlagworte: | MCOLN1, MG-2, Transient receptor potential channel mucolipin 1, Mucolipin-1, Mucolipidin |
| MW: | 66.5 kD |
ab 2.321,00 €
ML-SA1
Artikelnummer: Cay29958-10
ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by...
| Schlagworte: | Mucolipin synthetic agonist 1, 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
| Anwendung: | Mucolipin-1 (TRPML1) agonist |
| CAS | 332382-54-4 |
| MW: | 362.4 D |
ab 61,00 €
Mucolipin-1 (MCOLN1), human, recombinant
Artikelnummer: CSB-CF872417HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-580aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MTAPAGPRGS ETERLLTPNP GYGTQAGPSP APPTPPEEED LRRRLKYFFM SPCDKFRAKG RKPCKLMLQV VKILVVTVQL ILFGLSNQLA VTFREENTIA FRHLFLLGYS...
| Schlagworte: | ML4, ML1, MG-2, TRPML1, MSTP080, Mucolipidin, Mucolipin-1, Transient receptor potential channel mucolipin 1, Recombinant... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 66.5 kD |
ab 1.458,00 €
Anti-MCOLN1 / TRPML1
Artikelnummer: ARG41330.50
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | Anti-ML4, Anti-ML1, Anti-MG-2, Anti-TRPML1, Anti-MCOLN1, Anti-MSTP080, Anti-Mucolipidin, Anti-Mucolipin-1, Anti-Transient... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
551,00 €
Anti-MCOLN1
Artikelnummer: ATA-HPA031763.100
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | Anti-ML1, Anti-ML4, Anti-MG-2, Anti-TRPML1, Anti-MSTP080, Anti-Mucolipin-1, Anti-Mucolipidin, Anti-Transient receptor... |
| Anwendung: | ICC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 320,00 €
ML-SA5
Artikelnummer: Cay38326-1
ML-SA5 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It activates whole-endolysosome TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Cay-20425) (EC50 = 333 nM). ML-SA5 (3 µM) is cytotoxic to MeWo and M12 melanoma cells but not normal melanocytes. It induces...
| Schlagworte: | Mucolipin Synthetic Agonist 5, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-1,4-benzenedisulfonamide |
| Anwendung: | TRPML1 agonist |
| CAS | 2418670-70-7 |
| MW: | 458 D |
ab 41,00 €
Nanodisc Human MCLN1-Strep Protein
Artikelnummer: G-HDFP1392.10
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | ML1, ML4, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
1.336,00 €
Nanodisc Human MCLN1 Protein
Artikelnummer: G-HDFP677.10
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | ML1, ML4, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
1.486,00 €
Human MCLN1-Strep full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP120769.10
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2 ),...
| Schlagworte: | ML4, ML1, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 65 kD |
ab 1.162,00 €
Human MCLN1 full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100769.10
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2 ),...
| Schlagworte: | ML4, ML1, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 65 kD |
ab 1.291,00 €
MCOLN1 (Vector Vector will be determined during the...
Artikelnummer: CSB-CL872417HU.10
Length: 1743 Sequence: atgacagccc cggcgggtcc gcgcggctca gagaccgagc ggcttctgac ccccaacccc gggtatggga cccaggcggg gccttcaccg gcccctccga cacccccaga agaggaagac cttcgccgtc gtctcaaata ctttttcatg agtccctgcg acaagtttcg agccaagggc cgcaagccct gcaagctgat gctgcaagtg gtcaagatcc tggtggtcac ggtgcagctc atcctgtttg ggctcagtaa...
| Schlagworte: | ML1, ML4, MG-2, TRPML1, MSTP080, Mucolipidin, Mucolipin-1, Transient receptor potential channel mucolipin 1 |
| Anwendung: | Molecular biology, clone |
| Spezies-Reaktivität: | human |
357,00 €