Zu "K04992" wurden 19 Artikel gefunden!
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ML-SA1
Artikelnummer: Cay29958-10
ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by...
| Schlagworte: | Mucolipin synthetic agonist 1, 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
| Anwendung: | Mucolipin-1 (TRPML1) agonist |
| CAS | 332382-54-4 |
| MW: | 362.4 D |
ab 67,00 €
Anti-MCOLN1 / TRPML1
Artikelnummer: ARG41330.50
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | Anti-ML4, Anti-ML1, Anti-MG-2, Anti-TRPML1, Anti-MCOLN1, Anti-MSTP080, Anti-Mucolipidin, Anti-Mucolipin-1, Anti-Transient... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
584,00 €
Anti-MCOLN1
Artikelnummer: ATA-HPA031763.100
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | Anti-ML1, Anti-ML4, Anti-MG-2, Anti-TRPML1, Anti-MSTP080, Anti-Mucolipin-1, Anti-Mucolipidin, Anti-Transient receptor... |
| Anwendung: | ICC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
ML-SA5
Artikelnummer: Cay38326-1
ML-SA5 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It activates whole-endolysosome TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Cay-20425) (EC50 = 333 nM). ML-SA5 (3 µM) is cytotoxic to MeWo and M12 melanoma cells but not normal melanocytes. It induces...
| Schlagworte: | Mucolipin Synthetic Agonist 5, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-1,4-benzenedisulfonamide |
| Anwendung: | TRPML1 agonist |
| CAS | 2418670-70-7 |
| MW: | 458 D |
ab 45,00 €
Mucolipin-1 (MCOLN1), human, recombinant
Artikelnummer: CSB-CF872417HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-580aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MTAPAGPRGS ETERLLTPNP GYGTQAGPSP APPTPPEEED LRRRLKYFFM SPCDKFRAKG RKPCKLMLQV VKILVVTVQL ILFGLSNQLA VTFREENTIA FRHLFLLGYS...
| Schlagworte: | ML4, ML1, MG-2, TRPML1, MSTP080, Mucolipidin, Mucolipin-1, Transient receptor potential channel mucolipin 1, Recombinant... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 66.5 kD |
ab 1.458,00 €
ML-SA5
Artikelnummer: TGM-T60036-100mg
Description: ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. Target: Autophagy. Smiles: CN(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(Cl)c1N1CCCCC1. References: Qi J, et al. MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc...
| Anwendung: | TRPML1 agonist |
| CAS | 2418670-70-7 |
| MW: | 457.99 D |
ab 32,00 €
Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01710-100ug
Description: Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 66.5 kDa and the accession number is Q9GZU1.
| Schlagworte: | MCOLN1, MG-2, Transient receptor potential channel mucolipin 1, Mucolipin-1, Mucolipidin |
| MW: | 66.5 kD |
ab 1.421,00 €
NEU
Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01710-10ug
Description: Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 66.5 kDa and the accession number is Q9GZU1.
| Schlagworte: | MCOLN1 , ML4 , Mucolipidin , Mucolipin-1 , TRPML1 , MG-2 , Transient receptor potential channel mucolipin 1 (TRPML1) , ML1 |
| MW: | 66.5 kD |
ab 497,00 €
Nanodisc Human MCLN1-Strep Protein
Artikelnummer: G-HDFP1392.10
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | ML1, ML4, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
1.605,00 €
Nanodisc Human MCLN1 Protein
Artikelnummer: G-HDFP677.10
Protein function: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events,...
| Schlagworte: | ML1, ML4, MG-2, TRPML1, MSTP080, Mucolipin-1, Mucolipidin, Transient receptor potential channel mucolipin 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
1.693,00 €
MCOLN1, Human mucolipin 1, Real Time PCR Primer Set
Artikelnummer: VHPS-5618
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | ML4, MG-2, MCOLN1, MSTP080, Mucolipidin, Mucolipin-1 |
| Anwendung: | RNA quantification |
45,00 €
Mcoln1, Mouse mucolipin 1, Real Time PCR Primer Set
Artikelnummer: VMPS-3766
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Mcoln1, Mucolipin-1, Mucolipidin |
| Anwendung: | RNA quantification |
45,00 €