ML-298

ML-298 is an inhibitor of phospholipase D2 (PLD2, IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 µM without inducing cytotoxicity.Formal Name: 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide. CAS Number: 1426916-02-0. Molecular Formula: C22H23F3N4O2. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 203, 249 nm. SMILES: FC1=CC=C(C(NCCN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1F. InChi Code: InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31). InChi Key: XAPVAKKLQGLNOY-UHFFFAOYSA-N.