ML-277

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 µM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.Formal Name: (2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide. CAS Number: 1401242-74-7. Synonyms: CID-53347902. Molecular Formula: C23H25N3O4S2. Formula Weight: 471.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 242, 270 nm. SMILES: COC1=CC=C(C2=CSC(NC([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)=O)=N2)C=C1. InChi Code: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1. InChi Key: OXQNLLVUVDAEHC-OAQYLSRUSA-N.